ETV6: A Candidate Gene for Predisposition to “Blend Pedigrees”? A Case Report from the NEXT-Famly Clinical Trial

Figure 3

Quantification of ETV6 transcripts by dPCR. The quantification was performed on PBMCs RNA. ETV6 transcript levels were normalized for GAPDH transcript levels and expressed as ratio. Black block: affected relatives; Dark grey block: AML wt-ETV6 cases; Light grey block: healthy subjects. Affected relatives presenting 514C>T variants resulted with ETV6 statistically down regulated in comparison with AML cases presenting wild-type ETV6 ( ) and healthy controls (). PBMCs = peripheral blood mononuclear cells; AML = acute myeloid leukemia.