An Unusual Coexistence of Primary Central Nervous System Non-Hodgkin’s Lymphoma and Acute Promyelocytic Leukemia

Table 1

Laboratory values in the main time-points from hospital admission to PNCSL diagnosis.

	Admission 1 Sep 2014	7 Sep 2014	15 Sep 2014	1 Oct 2014	APL diagnosis and start of ATO-ATRA + prednisone 4 Oct 2014	After 7 days of ATO-ATRA + prednisone 11 Oct 2014	After 15 days of ATO-ATRA + prednisone 20 Oct 2014	At the end of ATO-ATRA induction + prednisone 31 Oct 2014	At PNCSL diagnosis 14 Nov 2014
Hb (g/dl)	13.5	13	13	13.3	13.4	10	8.8	10.1	12.6
WBC count (×10^9/L)	9	9.5	15	10	20	20.9	5.7	3.2	8.8
ANC (×10^9/L)	2.4	2.5	4.5	2.5	2.5	17.5	3.4	1.4	5.8
Blast cells (%)	0	10	60	64	70	11	12	0	0
Platelets (×10^9/L)	120	90	24	15	47	47	24	361	429
GOT (U/L)	20	19	19	17	15	64	49	35	16
GPT (U/L)	30	32	29	29	30	125	129	63	15
Creatinine (mg/dl)	0.9	0.9	0.9	0.9	0.9	0.7	0.6	0.5	0.6
Fibrinogen (mg/dl)	237	240	250	237	275	207	214	289	536
D-dimer (μg/ml)	698	690	2430	2400	9903	707	862	641	492
LDH (U/L)	240	230	300	309	304	448	227	186	195
PT (ratio)	1.06	1.07	1.05	1.07	1.13	0.95	0.92	1.01	1.03
aPTT (ratio)	0.87	0.89	0.85	0.88	0.91	0.78	0.78	0.9	1.07

Hb: hemoglobin (normal values 13.5–17.5 g/dl); WBC: white blood cell (normal values 4.8–10.8 × 10⁹/L); ANC: absolute neutrophil count (normal values 1.5–6.5 × 10⁹/L); GOT: aspartate transaminase (normal values 5–38 U/L); GPT: alanine aminotransferase (normal values 5–41 U/L); creatinine normal values 0.5–1.2 mg/dl; fibrinogen normal values 165–350 mg/dl; D-dimer normal values 0–230 μg/ml; LDH: lactate dehydrogenase (normal values 135–225 U/L); PT: prothrombin time (normal values 0.88–1.21 sec); aPTT: partial thromboplastin time (normal values 0.85–1.18 sec).