Case Report
Aberrant “Barbed-Wire” Nuclear Projections of Neutrophils in Trisomy 18 (Edwards Syndrome)
Table 1
Summary of case information in articles describing aberrant nuclear projections associated with chromosomal trisomies.
| Report (year) | Number of cases | Trisomy chromosome | Nuclear projections | Description | # per cell | Size | % of neutrophils |
| Huehns et al. (1964) [9] | 6 | D group | Extremely variable, sessile, pedunculated | 1–6 | 0.25–1.5 µm | ND | Powars et al. (1964) [12] | 1 | D group | Hook-like | ND | <2.0 µm | 63% |
Lutzner and Hecht (1966) [10] | 11 | D group () C group () | Varied greatly in size and shape, tags, threads, clubs, drumstick-like | 1–10 | ND | 60–80% |
Walzer et al. (1966) [11] | 11 | D group | Variable, spherical, ovoid or club shaped | 1–4 | 0.5–1.5 µm | 15–52%; Ave. = 26% | Dallapiccola et al. (1984) [14] | 1 | Mosaic 14 | Sessile, pedunculated | 3–6 | 0.25–1.5 µm | 40% | Salama et al. (2004) [13] | 1 | 13 | Thread-like | >2 | ND | 80% |
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(Ave.: average; ND: not determined).
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