Case Report
Allogeneic Hematopoietic Cell Transplantation for Therapy-Related Myeloid Leukemia following Orthotopic Cardiac Transplantation
Table 1
Clinical course and cytogenetic abnormalities of the patient.
| Time | 0 | 3 months | 6 months | 8 months | 12 months | 12 months |
| Clinical course | Acute Leukemia | Induction chemo | Relapse | Reinduction chemo + allo-HCT | CNS relapse | Systemic relapse | Treatment | Hydroxyurea | Cytarabine + mitoxantrone | | Cytarabine + mitoxantrone + allo-HCT (Flu/Mel/alemtuzumab) | Intrathecal methotrexate + hydrocortisone; cranial radiation | Cytarabine + Etoposide | Bone marrow biopsy | t-AML, 91% blasts | CR1 | Recurrent t-AML, 53% blasts | CR2 | | Recurrent t-AML, 40% blasts | Karyotype | 46XY, inv(9)c, t(10;11) | 46XY, inv(9)c | 46XY, inv(9)c, 20%; 46XY, inv(9)c, t(10;11), 75% | 46XY, 100% donor | | 46XY, inv(9)c, t(10;11) |
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