Chromosomal Abnormalities in Syndromic Orofacial Clefts: Report of Three Children

Table 1

Molecular karyotype with chromosomal base pair location, size, number of genes, and critical regions in the case series.

Proband	Molecular karyotype	Base pair location (mb)	Size (mb)	Number of genes	Critical regions
1.	arr11q23.3q25 x 3;	116.7 – 134.9	18.2	180	Duplicated material
	arr22q11.1q11.21 x 3	16.1 – 20.7	4.6	65
2.	arr4q27q35.2 x 3;	121.7 – 190.9	69	226	4q33q34 – Developmental disability; and craniofacial dysmorphism; 4q26q27 – Cardiac; 4q25q31.3 – Urogenital
	arr21q22.2q22.3 x 1	40.8 – 48.1	7.3	105
3.	arr12p13.33p13.32 x 3;	0.2 – 4.5	4.3	33	18q22.2q23 – Cleft lip palate
	arr18q22.3q23 x 1	70.9 – 78.0	7.1	28