Chromosomal Abnormalities in Syndromic Orofacial Clefts: Report of Three Children

Figure 2

Proband 2: (a) phenotype showing prominent nose, right cleft lip, and abnormal ear, (b) karyotype and ideogram showing derivative chromosome 21, (c) karyotype and ideogram of mother of proband showing t(4; 21)(q27; q22), (d) snapshots of microarray plots (Illumina HumanCytoSNP-12, CA) and coding genes (http://genome.ucsc.edu/) of duplication 4q27q35.2, and (e) snapshots of microarray plots (Illumina HumanCytoSNP-12, CA) and coding genes (http://genome.ucsc.edu/) of deletion 21q22.2q22.3.