Syringocystadenocarcinoma Papilliferum in a Fifteen-Year-Old Girl: A Case Report and Review of the Literature

Figure 3

The tumor was composed of both exophytic and underlying infiltrative components, the former showing a papillary pattern similar to syringocystadenoma papilliferum and the latter showing closely spaced tubular glands similar to tubular apocrine adenoma (a). Florid overgrowth of the outer epithelial cells produced complex, maze-like spaces between epithelial cells and cellular tufts off the surface of the tumor (b). The outer epithelial cells showed crowded, overlapping, atypical nuclei with prominent nucleoli with mitotic activity (c). The inner luminal cells of the dermal glands demonstrated bulbous, micropapillary projections (d). CK7 was diffusely expressed by both outer epithelial cells of the papillae and inner luminal cells of the dermal glands (e). P63-positive basal cells bordered the papillae and glands (f).