Interstitial Granulomatous Drug Reaction to Ustekinumab

Figure 2

Histopathology with H&E demonstrating (a) epidermal acanthosis and mild spongiosis at 100X. There is dense perivascular inflammation, and interstitial histiocytes are noted at the edge of the specimen. (b) Histiocytes are seen between collagen bundles as well as scattered eosinophils, 400X.