Case Report
An Atypical Presentation of Lichen Planus-Like Reaction from Pembrolizumab
Table 1
Skin and subcutaneous tissue disorders management of different gradings based on CTCAE (Common Terminology Criteria for Adverse Events) [
16].
| Grading (CTCAE) | General Cutaneous Features | Steroids | Immunosuppressives | Management of Immunotherapy | Outpatient or Inpatient care |
| 1 | Covers <10% BSA, limited, asymptomatic | Not recommended | Not recommended | Continue | Outpatient |
| 2 | Covers 10-30% BSA, minimal to moderate symptoms | Topical or systemic steroids oral 0.5-1 mg/kg/d | Not recommended | Continue | Outpatient |
| 3 | Covers >30% BSA, moderate or severe symptoms, limiting self-care ADLs | Systemic steroids oral or IV 1-2 mg/kg/d for 3 days then to 1mg/kg/d | Can consider if unresolved after 3-5 days of steroids | Suspend, discuss risk/benefit with patient | Outpatient or Inpatient for IV steroids |
| 4 | >30% BSA and fluid/electrolyte abnormalities | Systemic IV methylprednisolone 1-2mg/kg/d for 3 days | Can consider if unresolved after 3-5 days of steroids | Discontinue permanently | Inpatient and possible ICU or burn unit |
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BSA: body surface area.
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