Intravascular Large B-Cell Lymphoma in Acute Hypoxic Respiratory Failure

Figure 2

Time course of treatment of intravascular large B-cell lymphoma. NPPV: noninvasive positive pressure ventilation; HFNC: high-flow nasal cannula; Alb: albumin; Hb: hemoglobin; Plt: platelet; mPSL: methylprednisolone; PSL: prednisolone; LVFX: levofloxacin; TAZ/PIPC: tazobactam/piperacillin; R-CHOP: rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone. The patient’s respiratory condition did not improve after administering antibiotics or high steroid doses. NPPV and HFNC were used for respiratory support. Blood tests revealed a further decline in platelet count, albumin, and hemoglobin levels. On day 8, a random skin biopsy was performed; on day 12, the patient was diagnosed with IVLBCL after a skin biopsy. On day 14, the patient received R-CHOP therapy. After one chemotherapy cycle, the patient’s dyspnea gradually improved, and oxygen therapy was discontinued on day 24. The patient was discharged on day 30.