The Use of Membranes (ST-100, oXiris, and M60) for Continuous Renal Replacement Therapy in a Child with Sepsis

Table 2

The dynamics of clinical and laboratory parameters during CRRT.

Days after ICU admission	D1	D2	D3	D4	D5	D6	D7
Respiratory rate (b/min)	30	28	25	25	27	26	18
PEEP (cmH2O)	6	6	6	6	5	6	5
FiO2	50	60	60	50	40	35	35
PC above PEEP (cmH2O)	18	18	17	15	12	12	10
PaCO2 (cmH2O)	41.4	36	39.7	37.7	39.1	37.1	35.9
PaO2 (cmH2O)	90	105	114	120	128	115	111
P/F	180	175	190	240	320	328	317
Heart rate (b/min)	139	138	135	148	108	121	107
Mean arterial pressure (mmHg)	45	58	66	58	84	72	84
Noradrenaline (ug/kg/min)	0.2	0.5	0.6	1	0.6	0.7	0.6
Dobutamine (ug/kg/min)	5	7.5	12.5	12.5	10	10	7.5
Creatinine (μmol/L)	20	16	45	42	27	34	34
Urea nitrogen (mmol/L)	2.78	1.98	4.5	3.4	2.9	7.12	7.69
Urea (ml/24 h)	250	610	780	890	1030	1060	1230
CRRT parameters
Mode	/	CVVHDF	CVVHDF	CVVHDF	CVVHDF	CVVHDF	CVVHDF
Membrane	/	ST100	ST100	oXiris	oXiris	M60	M60
Duration (h)	/	14	14	12	12	13	14
Blood flow rate (ml/kg/h)	/	3	3	3.5	3.5	3.5	3.5
Replacement fluid rate (ml/kg/h)	/	30	30	40	40	40	40
Net ultrafiltration flowrate (ml/kg/h)	/	4	3	3	2	3	3

CRRT: continuous renal replacement therapy; CVVHDF: continuous venovenous hemodiafiltration; P/F ratio: PaO₂/FiO2 ratio.