Ethylene Glycol Intoxication Requiring ECMO Support

Figure 1

Ethylene glycol is metabolized via ADH to glycolaldehyde. Fomepizole and ethanol are competitive antagonists of ADH. The metabolic pathway leading from ethylene glycol to oxalate is shown. ADH: alcohol dehydrogenase; ALDH: aldehyde dehydrogenase; GO: glycolate oxidase; GR: glycolate reductase; LDH5: lactate dehydrogenase 5.