Dosing of Antimycotic Treatment in Sepsis–Induced Liver Dysfunction by Functional Liver Testing with LiMAx®

Table 1

Course of laboratory values.

Value	2^nd July	4^th July	5^th July	6^th July	7^th July	9^th July	10^th July	11^th July	12^th July	13^th July	17^th July	25^th July
Caspofungin dose (mg/d)	0.00	0.00	70.00	50.00	50.00	50.00	50.00	50.00	35.00	35.00	35.00	50.00
Bilirubin (mg/dL)	1.40	1.50	1.80	1.70	0.90	0.50	0.60	0.60	0.70	0.60	0.90	0.30
Creatinine (mg/dL)	1.12	1.35	1.55	1.72	2.30	3.58	2.94	2.71	1.95	1.32	0.74	0.83
INR	1.02	1.14	1.14	1.09	1.09	1.10	1.13	1.07	1.06	1.03	1.11	1.32
Leucocytes (Gpt/l)	22.40	22.40	66.50	41.90	31.00	23.30	47.70	37.30	23.00	12.80	11.00	6.90
Albumin g/dL	15.10	19.90	15.30	16.40	17.20	16.40	17.30	19.70	14.10	16.60	16.00	14.80
Quick (%)	83.00	81.00	79.00	87.00	87.00	86.00	82.00	89.00	91.00	95.00	85.00	65.00
CVVHD (yes/no)	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	No
MELD	21.00	23.00	23.00	23.00	21.00	21.00	21.00	21.00	21.00	21.00	21.00	23.00
MELD (without dialysis)	10	12	14	15	15	17	16	15	12	7	4	3
Mortality (%)	19.60	19.60	19.60	19.60	19.60	19.60	19.60	19.60	19.60	19.60	19.60	19.60
LiMAx (µg/kg/h)	351.00		201.00									402.00
ASAT (U/l)	113.00	124.00	89.00	82.00	101.00	102.00	75.00	372.00	168.00	78.00	40.00	21.00
ALAT (U/l)	84.00	59.00	46.00	43.00	52.00	67.00	56.00	225.00	158.00	108.00	46.00	39.00
Sodium (mmol/L)	145.00	153.00	144.00	154.00	151.00	146.00	147.00	149.00	149.00	152.00	143.00	146.00
Interleukin 6 (pg/mL)	124.70	561.70	323.00	165.20			746.10	87.60	126.10
CRP (mg/L)	144.30	130.10	250.80	226.90	157.80	84.10	80.20	141.00	105.70	70.80	77.40	114.90
Fibrinogen (g/L)	4.30	3.31	3.88	3.06	2.49	3.61	3.54	3.54	2.89	2.29	3.39	3.39
Lactate (mmol/L)	0.73	1.11	1.34	1.01	1.47	1.56	2.78	2.16	1.17	1.02	0.71	0.68