Research Article
Stability Study of Darunavir Ethanolate Tablets Applying a New Stability-Indicating HPLC Method
Table 5
Analytical parameters and their variations.
| Parameters | Variations |
| A | Chromatographic column | A: Waters Symmetrya | a: Agilenta | B | Wavelength | B: 267 nm | b: 268 nm | b′: 266 nm | C | Flow rate | C: 1.0 mL/min | c: 1.1 mL/min | c′: 0.9 mL/min | D | Mobile phase | D: 50 : 50b | d: 55 : 45b | d′: 45 : 55b | E | Sonication time | E: 10 min | e: 11 min | e′: 9 min | F | Room temperature | F: 25°C | f: 20°C | G | Acetonitrile brand | G: JTBaker | g: Tedia |
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aC18, 250 × 4.6 mm, 5 µm; bacetonitrile : water.
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