Clinical Study
A Comparative Study between Olanzapine and Risperidone Regarding Drug-Induced Electrocardiographic Changes
Table 2
Intragroup analysis of different parameters between baseline and final stage of the assessment.
| | Drug∖variable | Mean or number at baseline | Mean or number at ending | | df | | CI |
| | Olanzapine-HR | 86.91 ± 27.5 | 84.45 ± 22.5 | 0.84 | 294 | 0.40 | −3.29, 8.21 | | Risperidone-HR | 92 ± 21.5 | 89 ± 21 | 1.09 | 238 | 0.27 | −2.40, 8.40 | | Olanzapine-P-R interval | 0.13 ± 0.06 | 0.14 ± 0.06 | −1.4 | 294 | 0.15 | −0.02, 0.00 | | Risperidone-P-R interval | 0.14 ± 0.05 | 0.14 ± 0.05 | | | >0.05 | | | Olanzapine-QRS | 0.08 ± 0.02 | 0.082 ± 0.02 | | | >0.05 | | | Risperidone-QRS | 0.07 ± 0.02 | 0.079 ± 0.02 | | | >0.05 | | | Olanzapine-VAT | 0.03 ± 0.01 | 0.030 ± 0.01 | | | >0.05 | | | Risperidone-VAT | 0.02 ± 0.007 | 0.028 ± 0.007 | | | >0.05 | | | Olanzapine-QTcF | 0.40 ± 0.04 | 0.41 ± 0.06 | −1.68 | 294 | 0.09 | −0.02, 0.00 | | Risperidone-QTcF | 0.40 ± 0.02 | 0.41 ± 0.03 | −3.03 | 238 | 0.002 | −0.02, −0.00 | | Olanzapine-Normal axis (Vector) | 100% () | 97.29% () | | | 0.44 | | | Risperidone-Normal axis (Vector) | 100% () | 100% () | | | >0.05 | | | Olanzapine-normal interventricular conduction | 100% () | 97.29% () | | | 0.44 | | | Risperidone-normal interventricular conduction | 100% () | 100% () | | | >0.05 | | Olanzapine-
upright T wave | 100% () | 100% () | | | >0.05 | | | Risperidone-upright T wave | 100% () | 100% () | | | >0.05 | |
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HR: heart rate, QTcF: corrected QT by Fridericia’s formula, and VAT: ventricular activation time.
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