A Feasible Computational Fluid Dynamics Study for Relationships of Structural and Functional Alterations with Particle Depositions in Severe Asthmatic Lungs

Table 1

Demographic, PFT baseline (prebronchodilator), and maximal (postbronchodilator) lung functions and CT-based air-volumes of two healthy subjects and two severe asthmatics.

	Healthy subjects (HS)		Severe asthmatics (SA)
	HS 1	HS 2	SA 1	SA 2
Demographics
Gender (F, Female)	F	F	F	F
Age (yrs.)	59	29	61	48
BMI (kg/m^2)	23.7	22.2	32.4	23.9
Asthma duration (yrs.)	-	-	10.6	19.7
Baseline lung function (pre-bronchodilator)
FEV1 (liters) (% predicted)	2.97; (100%)	3.15; (94%)	1.19; (34%)	1.02; (40%)
FVC (liters) (% predicted)	3.82; (100%)	4.00; (101%)	1.83; (39%)	2.52; (80%)
FEV1/FVC (%)	78%	79%	65%	41%
Maximal lung function (post-bronchodilator)
(liters) (% predicted)	3.36; (107%)	3.17; (100%)	2.05; (72%)	1.17; (46%)
FVC (liters) (% predicted)	4.04; (103%)	3.94; (102%)	2.97; (74%)	3.11; (98%)
FEV1/FVC (%)	83%	80%	69%	38%
CT-based air-volumes
TLC (liters)	5.37	4.31	5.64	4.33
FRC (liters)	2.04	1.79	2.85	1.77

All subjects are Caucasians and nonsmokers. PFT and CT measurements were obtained in upright and supine positions, respectively. CT scans were performed after bronchodilator.