Quantitative Assessment of the Physiological Parameters Influencing QT Interval Response to Medication: Application of Computational Intelligence Tools

Table 3

Input vector selected for GP modeling.

Orig input number	Equation (2) label	Label	Description
(1)	-	CYP1A2	Liver CYP1A2 abundance [pmol/mg of protein]
(11)	-	CYP3A4	Liver CYP3A4 abundance [pmol/mg of protein]
(14)	-	Gut_CYP2C9	Gut CYP2C9 abundance [pmol/mg of protein]
(20)	-	Sex_Code	Patients’ gender [male/female]
(22)	-	Weight	Patients’ weight [kg]
(24)		BSA	Patients’ body surface area [m^2]
(29)	-	Cardiac_Output	Patient’s cardiac output [L/h]
(41)		K	Patients’ plasma potassium concentration [mM]
(42)		Na	Patients’ plasma sodium concentration [mM]
(43)		Ca2	Patients’ plasma calcium concentration [mM]
(44)		IKr_inhibition	Patients’ and drugs’ specific IKr current inhibition [0–100%]
(45)		IKs_inhibition	Patients’ and drugs’ specific IKs current inhibition [0–100%]
(46)		INa_inhibition	Patients’ and drugs’ specific INa current inhibition [0–100%]
(47)		ICa_inhibition	Patients’ and drugs’ specific ICa current inhibition [0–100%]
(49)	dQTc	dQTc	Output (QTc interval modification as compared to baseline)