Simulation of Atrial Fibrosis Using Coupled Myocyte-Fibroblast Cellular and Human Atrial Models

Figure 1

Illustration of myocyte/Fbs complex unit. The rectangle indicates a normal atrial myocyte, the ellipse indicates a myocyte/Fbs complex unit, and the circle around the myocyte indicates a fibroblast. (a) View of one myocyte/Fbs complex unit: a single human atrial myocyte is coupled a selected number of homogeneous fibroblasts via assigning an intercellular conductance (gap) [14]. In this study, the number of fibroblasts was 1 to 6. (b) Schematic representation of 2D atrial tissue: myocyte/Fbs complex unit that replaces the normal myocyte random existing in the tissue indicates the fibrosis proliferous area [15].

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