Mathematical Modeling of Biofilm Structures Using COMSTAT Data

Table 1

Biofilm growth parameters and kills rates associated with MEM and TOB.

Parameter	Parameter estimate	Interchannel variability (%)
(μm^3/μm^2)	39.5 (1.34)	21.8
(1/h)	0.0425 (0.0406)	11.1
(1/h/cu)	0.00301 (0.00011)	14.8
(1/h/cu)	0.00352 (0.000168)	20.9
(1/h/cu^2)	0.000473 (0.000083)	7.1
Residual Variability σ (μm^3/μm^2)	8.02	-

, maximum biofilm growth (in absence of drug); , biofilm growth rate (in absence of drug); , MEM kill rate; , TOB kill rate; , drug interaction kill rate (cu, concentration units, 1000ng/mL). Standard errors for the estimated parameters are in parenthesis.