Pathway-Based Kernel Boosting for the Analysis of Genome-Wide Association Studies

Figure 1

Graphical representation of rewiring step in data preparation. Nodes are representing genes in the pathway, while edges indicate interactions between the corresponding genes. Assume the gene depicted in grey is not represented by any genetic markers in the considered study and thus cannot be analyzed. To retain information about the (indirect) interaction of the two genes previously linked to the omitted gene, a new direct link is established between them. Its interaction type is determined by multiplication of the weights inherent to the two dropped links.