Research Article
Towards the Design of a Patient-Specific Virtual Tumour
| Parameter | Unit | Value | Description | Reference |
| | mm2⋅h−1 | | Proteases diffusion coefficient | [17] | | h−1 | 130 | Proteases production rate by sprout | [17] | | h−1 | 1.30 | Proteases decay rate | [17] |
| | mm2⋅h−1 | | Tumour proteases diffusion coefficient | Adapted from [17] | | h−1 | 3600 | Proteases production rate by tumour cells | Adapted from [17] | | h−1 | 0.21 | Tumour proteases decay rate | Adapted from [17] |
| | mm2⋅h−1 | | Growth factor diffusion coefficient | [18] | | s−1 | 0.0145 | Growth factor production rate by quiescent cells | Estimated | | h−1 | 0.65 | Growth factor decay rate | [19] | | h−1 | 1 | Consumption rate of growth factor by endothelial cells | [19] | | h−1 | 0.06 | Max consumption of growth factor by endothelial cells | [19] |
| | mm2⋅h−1 | | Oxygen diffusion coefficient | [20] | | mm−1⋅s−1 | | Vessels permeability to oxygen | [21] | | s−1 | 2.4 | Oxygen consumption rate by normal cells | Based on [22] | | s−1 | | Oxygen consumption rate by proliferative cells | Based on [21] | | s−1 | | Oxygen consumption rate by quiescent cells | Based on [21] |
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