Research Article
Investigating Mutations to Reduce Huntingtin Aggregation by Increasing Htt-N-Terminal Stability and Weakening Interactions with PolyQ Domain
Table 4
Aggregation potentials of top 20 results for Htt-N-term 3-point mutations computed by PASTA.
| Mutant | Best energy | % -helix | % coil |
| Native | | 76.47 | 23.53 | M1 | | 70.59 | 29.41 | M2 | | 76.47 | 23.53 | M3 | | 76.47 | 23.53 | M4 | | 70.59 | 29.41 | M5 | | 76.47 | 23.53 | M6 | | 70.59 | 29.41 | M7 | | 82.35 | 17.65 | M8 | | 76.47 | 23.53 | M9 | | 76.47 | 23.53 | M10 | | 76.47 | 23.53 | M11 | | 64.71 | 35.29 | M12 | | 76.47 | 23.53 | M13 | | 76.47 | 23.53 | M14 | | 64.71 | 35.29 | M15 | | 70.59 | 29.41 | M16 | | 70.59 | 29.41 | M17 | | 76.47 | 23.53 | M18 | | 76.47 | 23.53 | M19 | | 76.47 | 23.53 | M20 | | 76.47 | 23.53 |
|
|
Mutant M7 results in the lowest energy, highest % -helix, and lowest % coil.
|