Research Article
Investigating Mutations to Reduce Huntingtin Aggregation by Increasing Htt-N-Terminal Stability and Weakening Interactions with PolyQ Domain
Table 1
The top 3-point mutations in Htt-N-term with lowest
values.
| | Mutant | Sequence | | Mutations |
| | M1 | ---KK---------D-- | | L4K E5K K15D | | M2 | --KK----------D-- | | T3K L4K K15D | | M3 | --K-K---------D-- | | T3K E5K K15D | | M4 | ---KK---------E-- | | L4K E5K K15E | | M5 | --KK----------E-- | | T3K L4K K15E | | M6 | ---K-------K--D-- | | L4K E12K K15D | | M7 | --K-K---------E-- | | T3K E5K K15E | | M8 | --KKK------------ | | T3K L4K E5K | | M9 | ----K------K--D-- | | E5K E12K K15D | | M10 | --K--------K--D-- | | T3K E12K K15D | | M11 | ---K----------D-D | | L4K K15D F17D | | M12 | ----K---------D-D | | E5K K15D F17D | | M13 | --K-----------D-D | | T3K K15D F17D | | M14 | ---K----------D-E | | L4K K15D F17E | | M15 | -R-K----------D-- | | A2R L4K K15D | | M16 | ---K-------K--E-- | | L4K E12K K15E | | M17 | ----K---------D-E | | E5K K15D F17E | | M18 | -R--K---------D-- | | A2R E5K K15D | | M19 | --K-----------D-E | | T3K K15D F17E | | M20 | -RK-----------D-- | | A2R T3K K15D |
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