Investigating Mutations to Reduce Huntingtin Aggregation by Increasing Htt-N-Terminal Stability and Weakening Interactions with PolyQ Domain

Figure 3

MD results of mutants 1, 7, and 16. (a) A 52 ns RMSD plot of mutant (L4K E5K K15D) and (b) the RMSF plot of the same mutant. (c) A 50 ns RMSD plot of mutant (T3K E5K K15E) and (d) the RMSF values of the same mutant. (e) a 52 ns RMSD plot of mutant (L4K E12K K15E) and (f) the RMSF values of the same mutant. All structures appear to be stable and conserved.

(a) RMSD graph for the Htt-N-term M1 mutant

(b) RMSF graph for the Htt-N-term M1 mutant

(c) RMSD graph for the Htt-N-term M7 mutant

(d) RMSF graph for the Htt-N-term M7 mutant

(e) RMSD graph for the Htt-N-term M16 mutant

(f) RMSF graph for the Htt-N-term M16 mutant