Investigating Mutations to Reduce Huntingtin Aggregation by Increasing Htt-N-Terminal Stability and Weakening Interactions with PolyQ Domain

Figure 2

Single-point mutation landscape of the Htt-N-terminal region. Stable mutants have low energies (blue), while destabilizing mutations have the highest energies (red). Energies are in KCal/mol.

(a) Htt-N-terminal mutation landscape

(b) 2D projection of the landscape