Research Article
Investigating Mutations to Reduce Huntingtin Aggregation by Increasing Htt-N-Terminal Stability and Weakening Interactions with PolyQ Domain
Algorithm 1
Generating the mutational landscapes of the Htt-N-term.
(1) procedure GENERATELANDSCAPE(, ) | (2) if then | (3) return null | (4) end if | (5) List(“ARNDCQEGHILKMFPSTWYV”) | (6) | (7) for in [] do | (8) for in do | (9) mutate(position ≔ , mutation ≔ , ) | (10) createStructure(, ) | (11) calculateCoulombEnergy() | (12) calculateLJEnergy() | (13) calculateSolvationEnergy() | (14) | (15) end for | (16) end for | (17) | (18) end procedure |
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