Phantom Validation of Tc-99m Absolute Quantification in a SPECT/CT Commercial Device

Figure 3

(a) -MAA SPECT/CT prior to Y-90 radioembolisation after administration of 105.8 MBq of -MAA to the right lobe of the liver (volume = 1290 mL, segmentation in violet). In this specific case the recovered total activity on the SPECT field of view was 98.2 MBq that is 7% less than the total administered activity. Average activity concentration in the normal parenchyma was 35.6 kBq/ml (range: 0–151 kBq/ml, volume = 987 mL). In the region of high uptake (typical of tumor hypervascularisation, volume = 303 mL, segmented in green) the averaged activity concentration was 107 kBq/ml (range: 49–421 kBq/mL). (b) Bone SPECT/CT of a patient administered with 937 MBq of -labeled diphosphonates. A hot lesion due to a degenerative arthrosis is visible on the left lumbar posterior vertebral articulation (L5-S1) with average activity concentration of 224.5 kBq/mL (range: 172–328 kBq/mL) with an average bone uptake into the SPECT field of view of 60 kBq/mL ( g/mL).

(a)

(b)