In Silico Investigation into Cellular Mechanisms of Cardiac Alternans in Myocardial Ischemia

Figure 5

Simulations of the inactivation gate and APD after decreasing inactivation time constant in hyperkalemia. (a) Decreased inactivation time constant of the gate ; (b) voltage-dependent inactivation gate . Decreased made the gate recover completely before the next APD. The gate responded once during two consecutive beats in hyperkalemia without decreasing ; (c) APs with no alternans.

(a)

(b)

(c)