Computational and Mathematical Methods in Medicine

Research Article

Structure-Functional Prediction and Analysis of Cancer Mutation Effects in Protein Kinases

Table 2

Summary of modeled somatic kinase mutations.
KinaseMutationsActivation status
ABLL248V, T315I/L/NActivating
G321E, Y353H, L387MActivating
EGFRL718/PActivating
G719C/A/R/D/V/SActivating
G721DActivating
L747S/P/FActivating
V765M, V769L, T790M Activating
G796S, L833V, T854A Activating
D855Inactivating
L858R, L861Q/RActivating
BRAFG466E/V, D594E/V, G596RInactivating
L597V/S/Q/R/LActivating
A598V, T599I/A, V600E/K/R/MActivating
FGFR2I548V, N550K, E565G, E565A Activating
N549H, N540K, K526E, Activating
K660E, R678G, K641R, G663EActivating
E636K, M640I, I642V, R759Q, E475K Inactivating
D530N, A648T, G701SInactivating
FGFR3I538V, N540K, K650EActivating
K508Inactivating
FGFR4P712T, H713R, S772N, D127HActivating
K503MInactivating
MAP2K4Q142L, R134QActivating
R154W, P326L, S251N, N234IInactivating
DAPK3T112M, D161N, P216SInactivating
HCKD378GInactivating
LYND385GInactivating
LKB1D194VInactivating
FYNG410RInactivating
EPHA3R728L, K761N, D678E, G766E, D806NInactivating
MAPK8G171SInactivating
CDK11G175SInactivating
MAST205G655AInactivating
TRKBT695I, D751NInactivating
ERBB2I767M, D769H/Y, V773AV777L,Activating
T798M, G804S, Y835F, V842I,Activating
T862A, L866R, L869Q, R896CActivating
K753MInactivating
ERBB3V714M, Q809R, V855A, S846I, E298CActivating
ERBB4V696I, A748S, E785K, R757Q, P829Q, T901MNo effect on kinase activity
K726R, D818N, D836QInactivating