Research Article
Structure-Functional Prediction and Analysis of Cancer Mutation Effects in Protein Kinases
Table 1
Structurally conserved cancer mutation hotspots in protein kinase genes.
| | Reference (EGFR) | Segment | Number of mutations | Number of drivers | Mutations | Activation status |
| | L718 | P-loop | 4 | 4 | ABL L248V | Activating | | BRAF I462S | | EGFR L718P | | JAK3 L527P |
| | G721 | P-loop | 5 | 4 | EGFRG721 | Activating | | BRAF G464A/E/R/V | | caMLCK G601E | | MLK2 G107E | | NDR2 G99A | | AurC G52E |
| | T790 | Hinge | 6 | 5 | EGFR T790M | Activating | | ABL T315I/N | | FGFR4 V550M | | KIT T670E | | PDGFRa T674I | | NEK11 T108M |
| | G796 | Hinge | 5 | 5 | EGFR G796S | Activating | | ABL G321E | | ErbB2 G804S | | IRR G1065E | | LKB1 G135R |
| | D855 | Activation | 5 | 5 | BRAF D594E | Inactivating | | DAPK3 D161N | | HCK D378G | | LKB1 D194V | | LYN D385Y |
| | G857 | Activation | 6 | 5 | BRAF G596R | Inactivating | | EPHA3 G766E | | FYN G410R | | JNK1 G171S | | MAST2 G655A | | CDK11 G175S |
| | L858 | Activation | 3 | 3 | EGFR L858R | Activating | | BRAF L596V | | ErbB2 L866R |
| | L861 | Activation | 8 | 8 | EGFR L861Q/R | Activating | | ABL L387M | | BRAFV600D/E/G/K/L/M | | ErbB2 L869Q | | FLT3 D835E/F/H/N/V/Y | | KIT D816E/F/V/H/I/N/V | | MET D1246H/N/V | | PDGFRa D842I/V/Y |
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