Structure-Functional Prediction and Analysis of Cancer Mutation Effects in Protein Kinases

Figure 7

Structural mapping of cancer mutational hotspots in protein kinases. The mutational hotspots are displayed using the EGFR kinase (pdb entry 1M14). The C-helix devoid of cancer mutations and drivers is shown in blue. The green hinge region contains an excess of predicted driver mutations, and the red catalytic and activation loops contain an excess of both cancer mutations and predicted drivers. Green balls denote residues with 4 predicted driver mutations, yellow balls denote residues with 5 predicted driver mutations, and the red ball denotes L861, which is predicted to be a driver in eight different kinases.