Structure-Functional Prediction and Analysis of Cancer Mutation Effects in Protein Kinases
Figure 5
Structural distribution of protein kinase SNPs. The structural distribution of common SNPs (a), congenital disease-causing SNPs (b), and cancer-associated SNPs (c) is depicted along with the frequencies of SNPs within specific structural domains (d). In (a)–(c), green coloration represents regions with an SNP frequency equivalent to what would be expected by random chance, blue coloration represents regions statistically devoid of SNPS, and red coloration depicts regions statistically enriched in SNPs. Note that regions enriched and devoid of SNPs are different across the three mutation types, with minimal overlap. In (d) blue bars represent common SNPs, red bars represent disease causing SNPs, and black bars represent cancer associated SNPs.
