Membrane Protein Stability Analyses by Means of Protein Energy Profiles in Case of Nephrogenic Diabetes Insipidus
Figure 5
The multiple energy profile alignment (MEPAL) of V2R in bound and unbound state to AVP. Although being overall energetically well conserved, three regions showing distinct energy differences can be detected. These regions correspond to residues involved in AVP binding. This observation points to slight changes and rearrangements in the structure of V2R during the binding process.
