Associations between Histogram Analysis Parameters Derived from DCE-MRI and Histopathological Features including Expression of EGFR, p16, VEGF, Hif1-alpha, and p53 in HNSCC

Figure 2

A p16 positive oropharyngeal HNSCC. (a) K_trans map of the tumor. (b) Histogram of K_trans values. The histogram analysis parameters (min⁻¹) are as follows: mean = 0.42, min = 0.09, max = 0.70, p10 = 0.24, p25 = 0.35, p75 = 0.50, P90 = 0.57, median = 0.42, mode = 0.47, kurtosis = 2.78, skewness = −0.18, and entropy = 3.29. (c) K_ep map of the tumor. (d) Histogram of K_ep values. Estimated histogram analysis parameters (min⁻¹) are as follows: mean = 0.60, min = 0.18, max = 1.04, p10 = 0.38, p25 = 0.45, p75 = 0.75, p90 = 0.88, median = 0.58, mode = 0.45, kurtosis = 2.20, skewness = 0.24, and entropy = 2.93. (e) V_e map of the tumor. (f) Histogram of V_e values. Estimated histogram analysis parameters are as follows: mean = 0.71, min = 0.22, max = 0.99, p10 = 0.49, p25 = 0.58, p75 = 0.86, p90 = 0.92, median = 0.73, mode = 0.63, kurtosis = 2.33, skewness = −0.38, and entropy = 2.68. (g) EGFR staining, 49020 µm² stained area. (h) Her2 staining, 56207 µm² stained area. (i) VEGF staining, 42720 µm² stained area. (j) Hif1-alpha staining, 11134 µm² stained area. (k) P53 staining, 45011 µm² stained area.

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