Associations between Histogram Analysis Parameters Derived from DCE-MRI and Histopathological Features including Expression of EGFR, p16, VEGF, Hif1-alpha, and p53 in HNSCC

Figure 1

DCE-MRI and histopathological findings in a patient with histologically proven squamous cell carcinoma of the oropharynx. The p16 status is negative for this patient. (a) K_trans map of the tumor. (b) Histogram of K_trans values. The histogram analysis parameters (min⁻¹) are as follows: mean = 0.25, min = 0.05, max = 0.80, p10 = 0.10, p25 = 0.16, p75 = 0.32, p90 = 0.40, median = 0.24, mode = 0.27, kurtosis = 4.5, skewness = 0.93, and entropy = 3.17. (c) K_ep map of the tumor. (d) Histogram of K_ep values. Estimated histogram analysis parameters (min⁻¹) are as follows: mean = 0.63, min = 0.23, max = 1.0, p10 = 0.38, p25 = 0.46, p75 = 0.80, p90 = 0.92, median = 0.62, mode = 0.57, kurtosis = 1.89, skewness = 0.11, and entropy = 3.86. (e) V_e map of the tumor. (f) Histogram of V_e values. Estimated histogram analysis parameters are as follows: mean = 0.40, min = 0.08, max = 0.91, p10 = 0.18, p25 = 0.27, p75 = 0.53, p90 = 0.64, median = 0.39, mode = 0.25, kurtosis = 2.37, skewness = 0.29, and entropy = 3.72. (g) EGFR staining, 106866 µm² stained area. (h) Her2 staining, 57694 µm² stained area. (i) VEGF staining, 1177 µm² stained area. (j) Hif1-alpha staining, 27708 µm² stained area. (k) P53 staining, no staining is detectable in the carcinoma.

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