Histogram Analysis and Visual Heterogeneity of Diffusion-Weighted Imaging with Apparent Diffusion Coefficient Mapping in the Prediction of Molecular Subtypes of Invasive Breast Cancers

<div>55-year-old woman with human epidermal growth factor receptor 2- (HER2-) negative invasive ductal carcinoma of the left breast on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) (a), diffusion-weighted imaging (DWI) (b), apparent diffusion coefficient (ADC) map (c), histopathology (d), and HER2 staining (e). The histogram obtained (f) displayed a peak around 1.0 × 10<sup>−3</sup> mm<sup>2</sup>/s and Gaussian distribution, in spite of being classified as high heterogeneity on visual assessment.</div>

Contrast Media & Molecular Imaging

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Figure 2: Histogram Analysis and Visual Heterogeneity of Diffusion-Weighted Imaging with Apparent Diffusion Coefficient Mapping in the Prediction of Molecular Subtypes of Invasive Breast Cancers 

Figure 2 | Histogram Analysis and Visual Heterogeneity of Diffusion-Weighted Imaging with Apparent Diffusion Coefficient Mapping in the Prediction of Molecular Subtypes of Invasive Breast Cancers 