Evaluation of ^99mTc-HYNIC-VCAM-1_scFv as a Potential Qualitative and Semiquantitative Probe Targeting Various Tumors

Figure 6

Tissue biodistribution of ^99mTc-HYNIC-VCAM-1_scFv in tumor xenografts. Biodistribution of ^99mTc-HYNIC-VCAM-1_scFv was assessed in mice bearing B16F10 tumors at 1, 2, and 4 h postinjection ((a), ). The blocking study with excess VCAM-1_scFv was performed at 1 h after ^99mTc-HYNIC-VCAM-1_scFv injection in B16F10 tumor-bearing mice (b). Tumor-to-blood (T/B) and tumor-to-muscle (T/M) ratios in mice bearing B16F10 tumors at the indicated time points (c). Biodistribution was similarly examined in five tumor models at 4 h postinjection (d). The comparison of tumor uptake (e), T/B (f), and T/M (g) in the different tumors. , , , and .

(a)

(b)

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(d)

(e)

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(g)