Evaluating Hepatobiliary Transport with ¹⁸F-Labeled Bile Acids: The Effect of Radiolabel Position and Bile Acid Structure on Radiosynthesis and In Vitro and In Vivo Performance

Table 3

Metrics of the ¹⁸F labeled bile acids time-activity curves. The values are expressed as mean ± SD (n = 3). Significant differences compared to the 3β-[¹⁸F]FCA values are marked with . A value ≤ 0.05 was considered significant. GBI = gallbladder and intestines; AB = arterial blood.

	3β-[^18F]FCA	3α-[^18F]FCA	3β-[^18F]FGCA	3β-[^18F]FCDCA
AUC liver (% ID⋅min)	1785 ± 194	1065 ± 171	1907 ± 58	2449 ± 111
Max% ID liver (%)	63.80 ± 2.61	58.58 ± 3.19	63.58 ± 1.84	51.01 ± 3.94
Time-to-peak liver (min)	5.33 ± 0.24	3.33 ± 0.62	5.17 ± 0.62	10.17 ± 0.62
AUC GBI (% ID⋅min)	3499 ± 340	4184 ± 109	3021 ± 276	2515 ± 189
Max% ID GBI (%)	83.44 ± 9.27	88.70 ± 2.38	75.32 ± 6.30	60.93 ± 7.29
AUC AB concentration (MBq⋅min/mL)	13003 ± 1032	14007 ± 2150	10192 ± 1404	28437 ± 4380
Biliary clearance (mL/min)	0.46 ± 0.08	0.49 ± 0.10	0.47 ± 0.07	0.18 ± 0.04