Evaluating Hepatobiliary Transport with ¹⁸F-Labeled Bile Acids: The Effect of Radiolabel Position and Bile Acid Structure on Radiosynthesis and In Vitro and In Vivo Performance

Table 1

Radiosynthesis characteristics of the different ¹⁸F labeled bile acids. The overall synthesis time was 100 minutes. n.d.c. RY: nondecay corrected radiochemical yield. RP: radiochemical purity. Data are mean ± SD.

	n.d.c. RY (%); (n = 3)	^18F labeling of precursor (%); (n = 3)	RP (%)	LogD; (n = 3)
3α-[^18F]FCA	10.56 ± 2.02	30.31 ± 1.28	>99	0.92 ± 0.17
3β-[^18F]FGCA	4.28 ± 0.39	11.51 ± 2.55	>99	0.011 ± 0.037
3β-[^18F]FCDCA	9.57 ± 1.51	28.27 ± 5.02	>99	1.42 ± 0.16
12β-[^18F]FCA	<0.5	2.82 ± 1.14	NA	NA
7β-[^18F]FCA	<0.5	1.23 ± 0.26	NA	NA