Research Article

Evaluating Hepatobiliary Transport with 18F-Labeled Bile Acids: The Effect of Radiolabel Position and Bile Acid Structure on Radiosynthesis and In Vitro and In Vivo Performance

Figure 5

Representative Maximum Intensity Projection PET/CT of 9 MBq 3β-[18F]FGCA and 3β-[18F]FCDCA in a wild-type mouse (slice thickness: 12 mm). After intravenous injection, both tracers showed exclusive uptake in the liver (3–20 minutes). The 18F labeled bile acids were then excreted in gallbladder and intestines. Biliary excretion of 3β-[18F]FCDCA is visually slower than 3β-[18F]FGCA (20–60 minutes after injection).