Evaluating Hepatobiliary Transport with 18F-Labeled Bile Acids: The Effect of Radiolabel Position and Bile Acid Structure on Radiosynthesis and In Vitro and In Vivo Performance

<div>18F labeled bile acid analogues under investigation in the present study. Compounds 3α-[18F]fluorocholic acid (3α-[18F]FCA), 3β-[18F]fluorochenodeoxycholic acid (3β-[18F]FCDCA), and 3β-[18F]fluoroglycocholic acid (3β-[18F]FGCA) on the upper row differ in bile acid structure (cholic acid, chenodeoxycholic acid, and glycocholic acid) or 3 α/β position of the radiolabel. The structures 12β-[18F]fluorocholic acid (12β-[18F]FCA) and 7β-[18F]fluorocholic acid (7β-[18F]FCA) have the same cholic acid structure, but different position of the radiolabel (7 or 12).</div>

Contrast Media & Molecular Imaging

fig1

Figure 1

Figure 1: Evaluating Hepatobiliary Transport with 18F-Labeled Bile Acids: The Effect of Radiolabel Position and Bile Acid Structure on Radiosynthesis and In Vitro and In Vivo Performance

Figure 1 | Evaluating Hepatobiliary Transport with 18F-Labeled Bile Acids: The Effect of Radiolabel Position and Bile Acid Structure on Radiosynthesis and In Vitro and In Vivo Performance 