Research Article

Exploiting the Concept of Multivalency with 68Ga- and 89Zr-Labelled Fusarinine C-Minigastrin Bioconjugates for Targeting CCK2R Expression

Table 3

Corresponding tumour-to-organ ratios of 68Ga- and 89Zr-labelled bioconjugates; data are presented as mean ± SD.

68Ga-labelled89Zr-labelled
MonomerDimerTrimerMonomerDimerTrimer

Ratio T/O1 h1 h1 h2 h4 h1 h1 h1 h2 h4 h
Blood
Spleen
Pancreas
Stomach
Intestine
Kidneys
Liver
Heart
Lung
Muscle
Bone
A431-mock

Statistical analysis was performed using the Student’s -test with values indicating significant () difference (a) between mono- and dimer, (b) between mono- and trimer, (c) between di- and trimer, (d) between 68Ga-labelled tracers and corresponding 89Zr-labelled counterparts, (e) between 1 h and 2 h, and (f) between 2 h and 4 h of radiolabelled trimer.