Investigation of Newly Prepared Biodegradable ³²P-chromic Phosphate-polylactide-co-glycolide Seeds and Their Therapeutic Response Evaluation for Glioma Brachytherapy

Table 2

Biodistribution of ³²P-CP particle in nude mice bearing U87MG glioma after intratumor injection of ³²P-CP colloids ().

Tissue	Radioactivity distribution (%ID/g)
		0.5 d	1 d	2 d	4 d	8 d	16 d	32 d	48 d	64 d
Tumor	Mean; 1 SD	429.1; 110.2	455.60; 265.72	570.5; 159.4	470.76; 218.05	525.57; 52.21	676.25; 61.15	——	——	——
Blood	Mean; 1 SD	0.057; 0.021	0.073; 0.035	0.079; 0.010	0.046; 0.011	0.022; 0.047	0.048; 0.014	0.02; 0.011	0.079; 0.014	0.070; 0.012
Heart	Mean; 1 SD	0.171; 0.052	0.124; 0.013	0.232; 0.151	0.207; 0.105	0.148; 0.049	0.097; 0.054	0.009; 0.035	0.246; 0.113	0.183; 0.071
Liver	Mean; 1 SD	0.253; 0.110	0.146; 1.077	1.690; 0.745	1.656; 1.076	2.918; 0.076	1.219; 0.171	1.122; 2.037	2.629; 0.041	2.465; 0.016
Spleen	Mean; 1 SD	0.324; 0.197	0.249; 0.128	0.559; 0.121	1.241; 0.052	0.913; 0.021	0.769; 0.061	0.334; 0.087	0.469; 0.011	0.356; 0.019
Lung	Mean; 1 SD	0.233; 0.103	0.163; 0.018	0.239; 0.078	0.256; 0.127	0.433; 0.212	0.512; 0.015	0.222; 0.013	0.041; 0.021	0.052; 0.010
Kidney	Mean; 1 SD	0.192; 0.074	0.153; 0.028	0.269; 0.121	0.256; 0.127	0.019; 0.017	0.071; 0.092	0.210; 0.007	0.269; 0.034	0.056; 0.019
Stomach	Mean; 1 SD	0.056; 0.034	0.097; 0.003	0.016; 0.011	0.033; 0.008	0.019; 0.017	0.113; 0.011	0.241; 0.015	0.049; 0.021	0.036; 0.019
Intestine	Mean; 1 SD	0.203; 0.109	0.038; 0.012	0.154; 0.035	0.159; 0.063	0.156; 0.127	0.136; 0.051	0.408; 0.031	0.176; 0.063	0.248; 0.030
Pancreas	Mean; 1 SD	0.030; 0.024	0.101; 0.002	0.049; 0.011	0.074; 0.015	0.077; 0.024	0.182; 0.01	0.020; 0.021	0.035; 0.012	0.055; 0.022
Brain	Mean; 1 SD	0.017; 0.019	0.026; 0.021	0.011; 0.010	0.036; 0.023	0.024; 0.014	0.013; 0.011	0.008; 0.012	0.013; 0.021	0.024; 0.014
Thyroid	Mean; 1 SD	0.016; 0.021	0.077; 0.007	0.026; 0.011	0.044; 0.013	0.026; 0.015	0.022; 0.021	0.012; 0.011	0.021; 0.022	0.035; 0.013
Testis	Mean; 1 SD	0.022; 0.012	0.041; 0.013	0.038; 0.022	0.021; 0.008	0.042; 0.010	0.018; 0.031	0.029; 0.008	0.033; 0.016	0.036; 0.011
Bone	Mean; 1 SD	0.762; 0.421	2.343; 0.035	2.369; 0.121	3.856; 0.236	4.004; 1.093	3.541; 0.211	2.605; 0.084	2.869; 0.308	2.656; 0.182
Muscle	Mean; 1 SD	0.007; 0.003	0.083; 0.010	0.034; 0.015	0.043; 0.017	0.046; 0.023	0.092; 0.026	0.053; 0.017	0.049; 0.021	0.045; 0.020

ID: injected dose. 0.5, 1, 2, 4, 8, 16, 32, 48, and 64 d were time at which animals were anesthetized and sacrificed, blood was collected, tissues were weighed, and radioactivity was quantified. mice at each time point.