Investigation of Newly Prepared Biodegradable 32P-chromic Phosphate-polylactide-co-glycolide Seeds and Their Therapeutic Response Evaluation for Glioma Brachytherapy
Table 1
Biodistribution of 32P-CP particle in nude mice bearing U87MG glioma after intratumor implantation of 32P-CP-PLGA seed ().
Tissue
Radioactivity distribution (%ID/g)
0.5 d
1 d
2 d
4 d
8 d
16 d
32 d
48 d
64 d
Tumor
Mean 1 SD
556.686 24.016
547.778 61.301
626.172 76.528
666.063 59.454
724.118 132.290
903.226 128.155
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Blood
Mean 1 SD
0.007 0.004
0.008 0.008
0.016 0.008
0.020 0.017
0.017 0.013
0.018 0.011
0.010 0.000
0.019 0.005
0.010 0.004
Heart
Mean 1 SD
0.028 0.012
0.046 0.013
0.079 0.011
0.167 0.015
0.213 0.006
0.128 0.024
0.062 0.015
0.018 0.011
0.027 0.012
Liver
Mean 1 SD
0.020 0.010
0.035 0.082
0.179 0.115
0.656 0.136
1.125 0.038
0.738 0.100
0.430 0.037
0.369 0.041
0.165 0.016
Spleen
Mean 1 SD
0.031 0.030
0.069 0.028
0.369 0.121
0.556 0.078
0.913 0.221
0.538 0.061
0.321 0.087
0.469 0.011
0.253 0.112
Lung
Mean 1 SD
0.013 0.000
0.017 0.018
0.206 0.020
0.115 0.027
0.093 0.012
0.068 0.015
0.094 0.013
0.071 0.021
0.062 0.010
Kidney
Mean 1 SD
0.033 0.030
0.057 0.028
0.137 0.021
0.074 0.027
0.109 0.017
0.065 0.013
0.039 0.007
0.039 0.034
0.021 0.010
Stomach
Mean 1 SD
0.009 0.004
0.017 0.003
0.404 0.011
0.030 0.008
0.039 0.017
0.038 0.011
0.026 0.015
0.049 0.021
0.036 0.019
Intestine
Mean 1 SD
0.023 0.010
0.099 0.038
0.154 0.035
0.159 0.063
0.292 0.127
0.225 0.051
0.113 0.031
0.176 0.063
0.148 0.030
Pancreas
Mean 1 SD
0.008 0.000
0.024 0.002
0.125 0.011
0.312 0.015
0.057 0.024
0.051 0.01
0.043 0.021
0.035 0.012
0.055 0.022
Brain
Mean 1 SD
0.017 0.009
0.006 0.011
0.028 0.01
0.099 0.023
0.065 0.024
0.033 0.011
0.037 0.012
0.041 0.021
0.024 0.014
Thyroid
Mean 1 SD
0.016 0.000
0.034 0.007
0.026 0.011
0.044 0.013
0.032 0.015
0.042 0.021
0.032 0.011
0.041 0.022
0.035 0.013
Testis
Mean 1 SD
0.022 0.010
0.021 0.013
0.038 0.022
0.021 0.008
0.042 0.010
0.058 0.031
0.029 0.008
0.033 0.016
0.036 0.011
Bone
Mean 1 SD
0. 233 0.021
0.377 0.035
0.369 0.121
1.049 0.236
1.518 0.049
1.081 0.211
0.930 0.084
0.569 0.308
0.656 0.182
Muscle
Mean 1 SD
0.011 0.000
0.035 0.010
0.034 0.015
0.043 0.017
0.052 0.023
0.041 0.026
0.034 0.017
0.029 0.021
0.025 0.020
ID: injected dose. 0.5, 1, 2, 4, 8, 16, 32, 48, and 64 d were time at which animals were anesthetized and sacrificed, blood was collected, tissues were weighed, and radioactivity was quantified. mice at each time point.
