Targeted Optical Imaging Agents in Cancer: Focus on Clinical Applications

Figure 5

Peptides. (a) Chlorotoxin (CTX) is labeled with Cy5.5 (abs = 675 nm and em = 695 nm), also known as BLZ-100. (b) GE-137 is specific for c-Met and is labeled with Cy5 (abs = 645 nm and em = 665 nm), also known as EMI-137. (c) VRPMPLQ is labeled with fluorescein (abs = 490 nm and em = 520 nm). (d) Peptides ASYNYDA, KCCFPAQ, and QRHKPRE are labeled with either FITC or Cy5 via a linker (X = FITC or CY5). (e) Peptide specific for Her2 is labeled with IRDye800 via a thiol-maleimide (X = IRDYE800). (f) Cyclic peptide LS301 specific for integrin is labeled with cypate (abs = 778 nm and em = 805 nm). (g) ABY-029 affibody specific for EGFR is labeled with IRDye800 ((a) reprinted and modified with the permission from [102] and (b) reprinted with the permission from [78]).

(a)

(b)

(c)

(d)

(e)

(f)

(g)