Fluorine-19 Magnetic Resonance Imaging and Positron Emission Tomography of Tumor-Associated Macrophages and Tumor Metabolism

Figure 2

PET-MRI and histological findings on day 7. (a) Axial MR image of a mouse and (b) the corresponding PET image were merged. (c) The coregistered MR-PET image shows overlapping of low SUV regions and high MR signal regions in tumors (white arrow in (b) and (c)). (d) Overview of an H&E-stained section of a tumor excised after PET-MRI (scale bar: 2 mm). (e) High-magnification view of the central region of the H&E-stained section (indicated by a yellow box in (d); scale bar: 100 μm); fragmented nuclei and disrupted cell morphology are observed, along with hypocellularity. (f) High-magnification view of the peripheral region of the tumor (white box in (d); scale bar: 100 μm); cell morphology and nuclei are intact, while the cells are densely packed. PET, positron emission tomography; MRI, magnetic resonance imaging; SUV, standardized uptake value; H&E, hematoxylin and eosin.

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