Antibiofilm Activity and Synergistic Effects of Thymol-Loaded Poly (Lactic-Co-Glycolic Acid) Nanoparticles with Amikacin against Four Salmonella enterica Serovars

Table 3

Minimum biofilm eradication concentration (MBEC) of amikacin and thymol-loaded PLGA and the fractional inhibitory concentration index (FICI) of combination against S. enterica serovars.

Isolates	MBEC (μg/mL)				MBEC reduction fold		FICI (int.)
	Alone		Combined
	Ami	TH-NPs	Ami	Thy	Ami	TH-NPs
S. Typhi ATCC 6539	128	64	2	8	64	8	0.14 (S)
S. Typhi	128	64	1	16	128	4	0.26 (S)
S. Enteritidis	128	128	4	4	32	32	0.06 (S)
S. Typhimurium	64	64	1	16	64	4	0.27 (S)
S. Choleraesuis	64	128	0,5	16	128	8	0.13 (S)

MBEC: minimum biofilm eradication concentration; Ami: amikacin; TH-NPs: thymol-loaded PLGA nanoparticles; FICI: fractional inhibitory index; INT: interpretation; S: synergy.