Research Article

Impact of Negative Fluid Balance on Mortality and Outcome of Patients with Confirmed COVID-19

Table 3

Characteristics and clinical features of overall 294 COVID-19 infected patients.

All patients (n = 294)Deceased patients (n = 101)Survivor patients (n = 193)

Age, mean (SD) (y)64.33 (16.38)66.77 (16.56)63.01 (16.21)0.064

Sex
Male152 (51.71)66 (65.34)86 (44.55)0.001
Female142 (48.29)35 (34.66)107 (55.45)

Coexisting conditions
Hypertension159 (54.08)50 (49.50)109 (56.47)0.255
Diabetes80 (27.21)33 (32.67)47 (24.35)0.128
Malignancy16 (5.44)8 (7.92)8 (4.14)0.175
Cardiovascular disease61 (20.74)19 (18.81)42 (21.76)0.554
Chronic kidney disease16 (5.44)4 (3.96)12 (6.21)0.418
Respiratory disease20 (6.80)4 (3.96)16 (8.29)0.161
Heart disease196 (66.66)67 (66.33)129 (66.83)0.931
Heart failure61 (20.74)23 (22.77)38 (19.68)0.536
Critical illness187 (63.60)91 (90.09)96 (49.74)<0.001

Interleukin-6 (pg/mL), median (IQR)92.4 (35, 233.5)120.4 (56.3, 260.2)75.8 (21.6, 175.1)0.020

Procalcitonin (ng/mL), median (IQR)3.7 (1.1, 14.5)5.5 (3.2, 18.9)1.4 (1.2, 3.8)0.003

White blood cell count (×109/L)
1600–11000183 (62.25)62 (61.39)121 (62.69)0.826
11001–48400111 (37.75)39 (38.61)72 (37.30)

C-reactive protein (mg/L)
0.5–1037 (12.58)7 (6.94)30 (15.54)0.034
10–116257 (87.41)94 (93.06)163 (84.45)

Fluid balance during hospitalization, mL, median (IQR)−250 (−550, 240)150 (−100, 350)−390 (−570, 100)<0.001

Creatinine, mg/dL, median (IQR)2.6 (0.8, 4.1)2.2 (1.1, 4.2)2.4 (1.1, 4.1)0.053

Creatinine, mg/dL, median (IQR)2.4 (0.8, 3.8)2 (1, 4.2)2.2 (0.9, 4)0.032

Change of creatinine, mg/dL, median (IQR)0.2 (0.1, 0.3)0.2 (0.1, 0.28)0.2 (0.1, 0.3)0.943

All laboratory values from the day of admission. Before discharge from the hospital in survived patients and before death in deceased patients.