Development and Validation of a Prediction Model of the Risk of Pneumonia in Patients with SARS-CoV-2 Infection

Table 2

Univariate and multivariate logistic regression analyses of candidate predictors of pneumonia risk prediction models in the training cohort.

Characteristic	Univariate analysis		Multivariate analysis
	β (95% CI)/OR (95% CI)	value	β (95% CI)/OR (95% CI)	value
Gender		0.7178
Female	1.0
Male	1.11 (0.64, 1.91)
Age (year)	1.03 (1.02, 1.04)	<0.0001	1.03 (1.01, 1.05)	0.0095
WBC (10^9/L)	1.18 (1.04, 1.35)	0.0136	1.38 (0.46, 4.09)	0.5663
RBC (10^12/L)	0.70 (0.45, 1.07)	0.0978	2.77 (0.68, 11.32)	0.1549
HGB (g/L)	0.99 (0.98, 1.01)	0.1937
PLT (10^9/L)	1.00 (0.99, 1.00)	0.1753
%Neu (%)	1.03 (1.01, 1.05)	0.0051	0.76 (0.59, 0.99)	0.0415
%Lymph (%)	0.98 (0.96, 1.00)	0.0769	0.80 (0.61, 1.04)	0.0991
%Mon (%)	0.85 (0.77, 0.93)	0.0005	0.66 (0.50, 0.88)	0.0041
#Neu (10^9/L)	1.23 (1.06, 1.42)	0.0056	0.98 (0.24, 3.96)	0.9818
#Lymph (10^9/L)	0.99 (0.65, 1.51)	0.9585
#Mon (10^9/L)	0.53 (0.17, 1.65)	0.2730
HCT (%)	0.95 (0.90, 1.01)	0.0989	0.88 (0.75, 1.04)	0.1332
MCV (fL)	1.01 (0.97, 1.05)	0.5854
MCHC (g/L)	1.02 (0.99, 1.04)	0.2370
MCH (Pg)	1.05 (0.94, 1.16)	0.3793
RDW-SD (fL)	1.09 (1.00, 1.19)	0.0522	0.95 (0.81, 1.12)	0.5666
RDW-CV (%)	1.18 (0.90, 1.56)	0.2336
PDW (%)	2.35 (1.15, 4.82)	0.0195	1.44 (0.65, 3.16)	0.3659
MPV (fL)	1.53 (1.11, 2.11)	0.0097	18.62 (0.98, 355.15)	0.0519
PCT (%)	0.14 (0.00, 22.97)	0.4483
P-LCR (%)	1.05 (1.01, 1.10)	0.0178	0.70 (0.47, 1.04)	0.0773
InCRP (mg/L)	1.84 (1.46, 2.32)	<0.0001	1.89 (1.40, 2.55)	<0.0001
%Eos (%)	0.83 (0.68, 1.01)	0.0594	0.71 (0.50, 1.03)	0.0691
#Eos (10^9/L)	0.09 (0.00, 3.02)	0.1814
%Bas (%)	0.08 (0.01, 0.49)	0.0058	2.95 (0.97, 90.23)	0.5346
#Bas (10^9/L)	0.00 (0.00, 0.01)	0.0249	0.00 (0.00, inf.)	0.3203

WBC = white blood cells; RBC = red blood cells; HGB = hemoglobin; PLT = platelets; %Neu = neutrophils (percentage); %Lymph = lymphocytes (percentage); %Mon = monocytes (percentage); #Neu = neutrophils (number); #Lymph = lymphocytes (number); #Mon = monocytes (number); HCT = hematocrit; MCV = mean corpuscular volume; MCHC = mean corpuscular hemoglobin concentration; MCH = mean corpuscular hemoglobin; RDW-SD = red cell distribution width-standard deviation; RDW-CV = red cell distribution width-coefficient of variation; PDW = platelet distribution width; MPV = mean platelet volume; PCT = plateletcrit; P-LCR = platelet large cell ratio; InCRP = natural log-transformed value of CRP; %Eos = eosinophils (percentage); #Eos = eosinophils (number); %Bas = basophils (percentage); #Bas = basophils (number). Significance in bold in Table 2 indicates indicators with p values less than 0.05 in multivariate analysis.