Research Article
Development and Validation of a Prediction Model of the Risk of Pneumonia in Patients with SARS-CoV-2 Infection
Table 1
Baseline indicators in the training cohort and validation cohort.
| | Characteristic | Training cohort | Validation cohort | | No pneumonia | Incident pneumonia | value | No pneumonia | Incident pneumonia | value |
| | Participants | 99 | 106 | | 47 | 47 | | | Age (year) | 32.00 (14.00–86.00) | 61.50 (17.00–97.00) | <0.001 | 39.00 (17.00–79.00) | 69.00 (2.00–89.00) | <0.001 | | Gender | | | 0.718 | | | 0.668 | | Female | 52 (52.53%) | 53 (50.00%) | | 29 (61.70%) | 31 (65.96%) | | | Male | 47 (47.47%) | 53 (50.00%) | | 18 (38.30%) | 16 (34.04%) | | | CRP (mg/L) | 6.82 (0.00–154.30) | 18.60 (0.47–359.14) | <0.001 | 1.66 (0.00–115.27) | 28.21 (0.00–236.13) | <0.001 | | WBC (109/L) | 5.40 (1.41–10.36) | 5.53 (2.36–15.56) | 0.038 | 7.35 (2.43–9.42) | 6.82 (2.54–14.64) | 0.511 | | RBC (1012/L) | 4.86 (3.31–6.44) | 4.79 (2.78–6.55) | 0.178 | 4.90 (3.84–6.29) | 4.46 (3.30–5.62) | <0.001 | | HGB (g/L) | 146.00 (67.00–184.00) | 145.00 (93.00–192.00) | 0.224 | 141.00 (116.00–173.00) | 132.00 (100.00–171.00) | 0.002 | | PLT (109/L) | 185.00 (98.00–361.00) | 173.00 (51.00–460.00) | 0.090 | 269.00 (136.00–424.00) | 221.00 (59.00–579.00) | 0.008 | | %Neu (%) | 69.10 (29.00–89.30) | 70.65 (38.80–94.10) | 0.019 | 61.30 (44.70–82.10) | 71.40 (44.70–92.60) | <0.001 | | %Lymph (%) | 19.70 (4.40–60.60) | 20.00 (2.40–53.80) | 0.189 | 30.70 (8.90–47.60) | 19.40 (5.80–47.00) | <0.001 | | %Mon (%) | 9.40 (3.70–29.50) | 7.90 (1.40–20.10) | <0.001 | 7.00 (3.40–14.50) | 7.20 (1.50–19.30) | 0.295 | | %Eos (%) | 0.60 (0.00–8.00) | 0.25 (0.00–5.90) | 0.016 | 1.20 (0.00–11.20) | 0.70 (0.00–3.20) | 0.017 | | #Eos (109/L) | 0.03 (0.00–0.35) | 0.01 (0.00–0.36) | 0.057 | 0.08 (0.00–0.91) | 0.04 (0.00–0.23) | 0.022 | | %Bas (%) | 0.20 (0.00–7.50) | 0.10 (0.00–0.80) | 0.002 | 0.20 (0.00–0.70) | 0.10 (0.00–0.40) | 0.004 | | #Bas (109/L) | 0.01 (0.00–0.32) | 0.01 (0.00–0.03) | 0.049 | 0.01 (0.00–0.04) | 0.01 (0.00–0.02) | 0.001 | | #Neu (109/L) | 3.45 (0.72–8.25) | 3.75 (0.91–14.36) | 0.012 | 4.26 (1.47–6.85) | 4.67 (1.46–12.80) | 0.188 | | #Lymph (109/L) | 1.05 (0.23–3.56) | 1.06 (0.24–5.47) | 0.864 | 2.05 (0.73–3.34) | 1.19 (0.55–3.94) | <0.001 | | #Mon (109/L) | 0.48 (0.19–1.50) | 0.43 (0.08–1.51) | 0.216 | 0.48 (0.17–0.74) | 0.52 (0.14–1.14) | 0.388 | | HCT (%) | 42.10 (22.40–52.10) | 41.15 (26.00–53.30) | 0.135 | 42.50 (36.20–52.00) | 39.80 (30.90–49.00) | <0.001 | | MCV (fL) | 87.60 (55.30–98.10) | 87.55 (62.00–99.40) | 0.597 | 89.30 (66.10–105.00) | 89.70 (69.30–102.50) | 0.427 | | MCHC (g/L) | 350.00 (301.00–369.00) | 352.00 (298.00–376.00) | 0.147 | 331.00 (311.00–352.00) | 333.00 (315.00–353.00) | 0.198 | | MCH (Pg) | 30.70 (16.70–33.90) | 30.90 (20.10–35.20) | 0.286 | 30.10 (21.00–34.40) | 30.10 (22.30–35.30) | 0.276 | | RDW-SD (fL) | 39.40 (33.30–55.50) | 40.15 (33.70–49.60) | 0.040 | 40.50 (36.00–48.50) | 40.20 (32.50–49.90) | 0.771 | | RDW-CV (%) | 12.20 (11.30–19.90) | 12.40 (11.30–17.40) | 0.096 | 12.10 (11.10–15.90) | 12.20 (10.90–14.00) | 0.803 | | PDW (%) | 16.20 (10.20–17.10) | 16.30 (15.40–17.80) | 0.014 | 16.20 (15.60–16.80) | 16.30 (15.70–17.40) | 0.112 | | MPV (fL) | 9.50 (7.30–11.90) | 9.80 (8.00–12.40) | 0.020 | 9.30 (7.70–11.70) | 9.50 (7.20–12.30) | 0.122 | | PCT (%) | 0.18 (0.10–0.34) | 0.17 (0.05–0.41) | 0.247 | 0.25 (0.14–0.36) | 0.20 (0.06–0.53) | 0.010 | | P-LCR (%) | 23.80 (8.80–41.90) | 26.10 (12.40–44.90) | 0.033 | 21.70 (12.60–39.20) | 24.20 (10.00–42.60) | 0.226 |
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CRP = C reactive protein; WBC = white blood cells; RBC = red blood cells; HGB = hemoglobin; PLT = platelets; %Neu = neutrophils (percentage); %Lymph = lymphocytes (percentage); %Mon = monocytes (percentage); %Eos = eosinophils (percentage); #Eos = eosinophils (number); %Bas = basophils (percentage); #Bas = basophils (number); #Neu = neutrophils (number); #Lymph = lymphocytes (number); #Mon = monocytes (number); HCT = hematocrit; MCV = mean corpuscular volume; MCHC = mean corpuscular hemoglobin concentration; MCH = mean corpuscular hemoglobin; RDW-SD = red cell distribution width-standard deviation; RDW-CV = red cell distribution width-coefficient of variation; PDW = platelet distribution width; MPV = mean platelet volume; PCT = plateletcrit; P-LCR = platelet large cell ratio.
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